Pharmacokinetics

Aim

Pharmacokinetic research is fundamentally important for the development, registration and application of new drugs. This post-doctoral course discusses the most important novel approaches in human-drug relations:

• Absorption, in relation to drug delivery pathways and forms;
• Distribution, a.o. lipid binding, blood-brain barrier and placenta passage;
• Excretion, through urine, bile, saliva and breast milk;
• Biotransformation, i.e. the various Cytochrome P450 enzymes and the origin of genetically induced polymorphisms, conversion speed, induction, inhibition, saturation and interactions.

Following a general introduction, these processes will be discussed according to pharmacokinetic parameter clearance, partition volume, and half-life. With a problem-orientated approach, the focus will be on the interpretation of pharmacokinetic data, both in healthy volunteers, as well as in patients (i.e. suffering from kidney insufficiency and liver illness). Additionally, the role of pharmacokinetic studies in drug registration will be addressed. The course will be concluded with a discussion on the relations between pharmacokinetics and pharmacodynamics.

Location & Organization

Organizer

LACDR - Leiden/Amsterdam Center for Drug Research

Faculty / Teachers

LACDR

Location / venue

Oegstgeest, Oud Poelgeest

Costs

1150 euro

Timing & Workload

Duration Three days
 

Teaching methods used

Lectures, practicals, examples and case studies, discussions.

Examination no

Criteria

Is the course taught in English? yes
Is documentation available? (book, syllabus)? yes
Is the course open for external researchers? yes

More Information

http://www.lacdr.nl/events/course-on-pharmacokinetics