Cell signaling in cancer

Aim

The cell signaling pathways include a complex myriad of interconnected factors from the membrane to the nucleus, via receptor activation, the phosphoinositide-3-kinase/Akt pathway and Ras-Raf-ERK cascades, which drive proliferative signals, promote survival, and regulate protein synthesis. The Wnt/beta-catenin pathway has a well-established role in cancer and will also be discussed. Activation of Rac1 mediates activation of actin in the leading edge of migrating cell. The regulation of the actin cytoskeletal network, cell adhesion and migration will also be covered.
Experimental design: To investigate pivotal factors in these pathways in cancer cells (breast and colon cancer) with immunohistochemical methods, Western blot techniques, cell migration and adhesion assays.

Location & Organization

Organizer

FLÄK - The Research School in Pharmaceutical Sciences

Course Director

Anita Sjölander

Location / venue

Lund University Malmö

Timing & Workload

Duration 1 week
ECTS points 3
Frequency Annual
 

Examination yes

Criteria

Is the course taught in English? yes
Is documentation available? (book, syllabus)? yes
Is the course open for external researchers? yes

More Information

http://www.biol.lu.se/cellorgbiol/postgrad/courses/course_17.html